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Cladribine is an antimetabolite that uniquely destroys resting and dividing lymphocytes equally It is also potently toxic to monocytes,13 which may explain its potential application to the treatment of monocyte-derived neoplasms and chronic inflammatory conditions, like multiple sclerosis,27 A further potential mechanism of action of cladribine in LCH may be through T-cell depletion, as cladribine Cited by: Jul 15,  · Conclusions: Bolus cladribine is a safe, convenient and effective therapy for adults with LCH, even when heavily pretreated; unmaintained durable remissions can be achieved in a subset of pts.. Long term follow-up of these pts. is necessary since myelodysplasia may complicate cladribine treatment. Author DisclosureCited by: 2.

Cladribine therapy may be beneficial in advanced forms of pulmonary Langerhans cell histiocytosis, even that with multiple cystic changesgeishax.xyz To the Editor: Langerhans cell histiocytosis (LCH) is a group of disorders with variable presentations and outcomes. Children with LCH primarily have bone and multisystem involvement with little . Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs.

Saven A, Burian C () Cladribine activity in adult Langerhans cell histiocytosis. Blood Adam Z, Szturz P, Duras J, Pour L, Kreji M, et al. () Treatment of Langerhans cell histiocytosis by cladribine reached long-term complete remission in 9 out of 10 adult patients. Klin Onkol Author: Marlies E.H.M. van Hoef. Most treatment and outcomes data in LCH are derived from pediatric studies, and there is a lack of FDA-approved treatment options for adult LCH. There is some evidence that cladribine may be toxic to monocytes and monocyte-derived dendritic cells. In this study, we report the efficacy of cladribine in adult LCH patients seen at our institution. Methods. We retrospectively reviewed the charts of all LCH Cited by: 1.

Jun 15,  · Cladribine is an antimetabolite that uniquely destroys resting and dividing lymphocytes equally It is also potently toxic to monocytes,13 which may explain its potential application to the treatment of monocyte-derived neoplasms and chronic inflammatory conditions, like multiple sclerosis, 27 A further potential mechanism of action of cladribine in LCH may be through T-cell depletion, as cladribine Cited by: The incidence of LCH is reported to be 3‐5/million; the majority of patients are children younger than 3 years and the incidence in adults is approximately 1‐2/million. 6 Incidence appears to be higher in Caucasians in northern European countries, and lower in Asia and Africa. 7.